Pfizer 据说改配方了?

Pfizer adds ingredient used to stabilize heart attack victims in vax for kids

https://www.fda.gov/media/153447/download
Read the Vaccine formulation section in page 14

小样儿,换个马甲就以为我认不出你了?

下面就是说为了疫苗更好的保存, 更加stable,解冻好可以冷藏10周,原来加在vaccine里的phosphate buffered saline,sodium chloride 和potassium chloride被拿出来了,护士要等用的时候再加入。

Sodium chloride 和potassium chloride是什么呢,简单点说就是盐。
一般的药和active pharmaceutical ingredients都有stability test的, 这也决定医药的shelf life。

To provide a vaccine with an improved stability profile, the Pfizer-BioNTech COVID-19 Vaccine
for use in children 5-11 years of age uses tromethamine (Tris) buffer instead of the phosphate buffered saline (PBS) as used in the previous formulation and excludes sodium chloride and
potassium chloride. The packaged vials for the new formulation are stored frozen at -90°C to -
60°C. The frozen vials may be thawed and stored at refrigerator at 2°C to 8°C for up to 10
weeks.
The Pfizer‑BioNTech COVID-19 Vaccine does not contain preservative. The vial stoppers are
not made with natural rubber latex. For the 10-μg RNA dose, each 1.3-mL filled via vial must be
diluted with 1.3mL 0.9% sodium chloride for injection to provide 10 doses at 10 μg RNA / 0.2 mL
Injection volume. After dilution, the vials should be stored at 2°C to 25°C and should be used
within 12 hours.

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这个成分Tromethamine用于治疗代谢性酸中毒。比如心脏搭桥手术,或者心梗。

换成这个原理还是一样的啊,也是为了保存和stable。
看下面,这个在这里用的是buffer,Tris是很多化妆品,药品里用的buffer, 完全安全的。也是很多药物里的一种ingridience 或者 buffer, 这个和vaccine不搭边啊。不能说药里的一种inactive ingredients只能在一种药里用吧。

Buffer 是干什么用的呢, buffer solution 一般就是stabliser, 就是稳定PH值之类的作用,这样药物比较stable。

An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer.

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Yeah, same principal as adding 泻立停 into 麻辣烫, i.e. to make the food stable, so one won’t go to the toilet when enjoying the delicious food :slight_smile:

低盐低糖更健康,加量不加价

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FDA 也approve泻立停 麻辣烫了吗?
你不打不就好了,也别吃麻辣烫:joy:

继续学习2021年11月2日发表的最新论文

Pfizer research organization falsified data in their Phase III COVID-19 vaccine trial results and fired those who complained about unethical trial practices to the FDA, according to a BMJ investigation, citing a whistleblower.

https://www.bmj.com/content/bmj/375/bmj.n2635.full.pdf

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继续学习今天的新闻

CEO of Pfizer arrested, charged with fraud – media blackout – Conservative Beaver

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你一天到晚发假新闻啊, 服了 :joy:

不要光看标题,自己去读一读,对你的英文提高也有好处。 :stuck_out_tongue_winking_eye:

这可不是我发的,只是转载而已,兼听则明嘛

来,学习一下这个今天最新的

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今天的新闻 – 52岁的心脏病专家

另外一个教授

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可怜的兄妹俩

https://www.hollywoodlanews.com/soccer-player-cardiac-arrest-brother/

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西医本来就是改来改去了,很正常吧

飞行员三个月前通过全面体检获得健康证明,两周前接种了第二针疫苗,飞行中途心肌炎导致致命的心脏病发作。

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这个飞行员,也太倒霉了吧

Peer reviewed paper published on 28 November 2021 in a leading journal Clinical Infectious Diseases (CID) with Impact Factor of 9.079

Conclusions

There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose.